Integrated Science of Synthesis by Chemical Structure Reprogramming

Research Groups

Overview

This research initiative comprises three specialized groups, A01 to A03, each focusing on distinct target substances, alongside the Physical Chemistry Group (A04), which provides analytical and simulation support. The realization of Structural Re-Programming (SReP) is achievable only through the collaborative efforts of these groups. The following sections provide an overview of the individual research contributions of each group and their collaborative endeavors.

A01 (Organic G): Focused on SReP methods for organic molecules, Group A01 spearheads the development of three fundamental technologies: cleavage of strong chemical bonds, editing of ring frameworks, and manipulation of stereochemistry. The group’s forte lies in crafting precise chemical structures through molecular design. These activities will not only benefit organic synthesis but also facilitate SReP in inorganic materials (A02) and macromolecules (A03).

A02 (Inorganic G): Tasked with advancing SReP techniques for inorganic materials such as metal complexes, metal clusters/nanoparticles, and oxide clusters, Group A02 addresses the challenge of precise control and post-editing of inorganic chemical structures. Leveraging molecular approaches, including designed ligands and templates in collaboration with A01, this group also aims to harness its unique inorganic materials as catalysts for SReP in organic molecules (A01) and macromolecules (A03).

A03 (Macromol G): This group specializes in SReP across a diverse array of macromolecules, ranging from proteins and nucleic acids to synthetic polymers and supramolecules. By providing tailored molecular structures, Group A03 will also develop entities with unique molecular recognition abilities, which can serve as distinctive reaction sites for both A01 and A02.

A04 (PhysChem G): This group promotes and aids the development of SReP across A01-A03 by leveraging its advanced measurement, analysis, and simulation capabilities. The group contributes to elucidating the science of SReP through electronic structure analysis, structural elucidation, mechanistic studies, and theoretical chemical calculations. Utilizing cutting-edge methodologies such as spatio-temporal analysis via operando measurements with synchrotron radiation spectroscopy, Group A04 ensures comprehensive insights into SReP mechanisms.